Open Problems in Synthetic Multicellularity

Ricard Sole, Nuria Conde , Jordi Pla Mauri , Jordi Garcia Ojalvo , Nuria Montserrat , Michael Levin

Multicellularity is one of the major evolutionary transitions, and its rise provided the ingredients for the emergence of a biosphere inhabited by complex organisms. Over the last decades, the potential for bioengineering multicellular systems has been instrumental in interrogating nature and exploring novel paths to regeneration and disease, as well as cognition and behaviour. Here, we provide a list of open problems that encapsulate many of the ongoing and future challenges in the field, and we suggest conceptual approaches that may facilitate progress.

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