Jesse S. Bettinger, Karl J. Friston

Neuroscience & Biobehavioral Reviews

Since the late nineteen-nineties, the concept of homeostasis has been contextualized within a broader class of “allostatic” dynamics characterized by a wider-berth of causal factors including social, psychological and environmental entailments; the fundamental nature of integrated brain-body dynamics; plus the role of anticipatory, top-down constraints supplied by intrinsic regulatory models. Many of these evidentiary factors are integral in original descriptions of homeostasis; subsequently integrated; and/or cite more-general operating principles of self-organization. As a result, the concept of allostasis may be generalized to a larger category of variational systems in biology, engineering and physics in terms of advances in complex systems, statistical mechanics and dynamics involving heterogenous (hierarchical/heterarchical, modular) systems like brain-networks and the internal milieu. This paper offers a three-part treatment. 1) interpret “allostasis” to emphasize a variational and relational foundation of physiological stability; 2) adapt the role of allostasis as “stability through change” to include a “return to stability” and 3) reframe the model of homeostasis with a conceptual model of criticality that licenses the upgrade to variational dynamics.

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