[ Your Name ]  would like to inform you about this article on
Complexity Digest 2010.13 - 11
http://comdig.unam.mx/index.php?id_issue=2010.13#33675
2010/06/18

[ Your Message ]

Editor-in-Chief: Carlos Gershenson
Founding Editor: Gottfried Mayer

Title: Evolution of Metabolic Networks: A Computational Framework, SFI Working
Papers
 









Excerpt: The metabolic architectures of extant organisms share many key pathways
such as the citric acid cycle, glycolysis, or the biosynthesis of most amino
acids. Several competing hypotheses for the evolutionary mechanisms that shape
metabolic networks have been discussed in the literature, each of which finds
support from comparative analysis of extant genomes. Alternatively, the
principles of metabolic evolution can be studied by direct computer simulation.
This requires, however, an explicit implementation of all pertinent components:
a universe of chemical reaction upon which the metabolism is built, an explicit
representation of the enzymes that implement the metabolism, of a genetic system
that encodes these enzymes, and of a fitness function that can be selected for.
Source: Title: Evolution of Metabolic Networks: A Computational Framework[
http://www.santafe.edu/research/working-papers/abstract/37465636cdf3b6cee5af44c201e3d59a/
], Christoph Flamm, Alexander Ullrich, Ullrich Ekker, Martin Mann, Daniel
Högerl, Markus Rohrschneider, Sebastian Sauer, Gerik Scheuermann, Konstantin
Klemm, Ivo L. Hofacker, Peter F. Stadler, DOI: SFI-WP 10-02-006, SFI Working
Papers

You can discuss this article on Articles Forum
http://comdig.unam.mx/topic.php?id_article=33675