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Complexity Digest 2001.34 - 13
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20-Aug-2001

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Structural Mimicry In		Bacterial Virulence, Nature
 









Excerpts: An important mechanism underlying the
strategies used by microbial pathogens to manipulate cellular
functions is that of functional mimicry of host activities.
(…) convergent evolution has produced new effectors that,
although having no obvious amino-acid sequence similarity to host
factors, are revealed by structural studies to display mimicry at
the molecular level.

Such a protein would usually have a distinct
three-dimensional architecture from that of the molecule it
mimics, but would typically have evolved to imitate the chemical
groups on the surface of its functional homologue.



Structural
Mimicry In Bacterial
Virulence, C E Stebbins
& J E Galan, Nature 412, 701 - 705 (2001)



 

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