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07-May-2001

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Regulation Of Differentiation		To The Infective Stage Of Protozoan Parasite,
Science
 









Excerpt: (...) During its infectious cycle, the human
pathogenic protozoan Leishmania spp. alternates between
flagellated promastigote forms, which grow within the alimentary
tract of the sand fly vector, and aflagellate amastigotes, which
replicate within acidified phagolysosomes of vertebrate host
macrophages. A critical step is metacyclogenesis, the
differentiation of the noninfective procyclic promastigote to the
highly infective metacyclic form within the sand fly (1). Several
genes showing metacyclic-specific expression have been identified
(2); however, the molecular mechanism(s) underlying the initiation
and control of this vital step remain undefined. (...)



Regulation
of Differentiation to the Infective Stage of the
Protozoan Parasite _Leishmania major_ by
Tetrahydrobiopterin,
Mark L. Cunningham, Richard G. Titus, Salvatore J.
Turco, Stephen M. Beverley, Science 292:285,
01/04/13



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