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Complexity Digest 2004.32 - 10.01
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09-Aug-2004

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Modeling A Synthetic Multicellular Clock: Repressilators Coupled By Quorum
Sensing, PNAS
 









Author's Summary: This paper asks how one might couple a population of synthetic
gene
oscillators, known as "repressilators," in such a way that they will
self-synchronize, despite the heterogeneity in the cells themselves.  The
scheme proposed here seems to be biochemically feasible, and works well in
numerical simulations.  It relies on the sort of technical wizardry made
possible today by genetic engineering; the cells are coaxed to interact by
the "quorum-sensing" mechanism that operates between certain bacterial
cells, mediated by the diffusion of a signaling molecule.  The goal is to
synthesize the analog of a multicellular biological clock.
 (See more detailed summary.)
Source: Modeling A Synthetic Multicellular Clock: Repressilators Coupled By
Quorum Sensing[ http://www.pnas.org/cgi/content/abstract/101/30/10955 ], Jordi
Garcia-Ojalvo, Michael B. Elowitz, Steven H. Strogatz, PNAS, vol. 101 | no. 30 |
10955-10960, 04/07/27

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