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27-Jan-2003

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Hormesis: The Dose-Response Revolution, Annu. Rev. Pharmacol. Toxicol.
 









Excerpts: Hormesis, a dose-response relationship phenomenon characterized by
low-dose stimulation and high-dose inhibition, has been frequently observed in
properly designed studies and is broadly generalizable as being independent of
chemical/physical agent, biological model, and endpoint measured. This
under-recognized and -appreciated concept has the potential to profoundly change
toxicology and its related disciplines with respect to study design, animal
model selection, endpoint selection, risk assessment methods, and numerous other
aspects, including chemotherapeutics. This article indicates that as a result of
hormesis, fundamental changes in the concept and conduct of toxicology and risk
assessment should be made, including (a) the definition of toxicology, (b) the
process of hazard (e.g., including study design, selection of biological model,
dose number and distribution, endpoint measured, and temporal sequence) and risk
assessment [e.g., concept of NOAEL (no observed adverse ! effect level), low
dose modeling, recognition of beneficial as well as harmful responses] for all
agents, and (c) the harmonization of cancer and noncancer risk assessment.
Source: Hormesis: The Dose-Response Revolution[
http://pharmtox.annualreviews.org/cgi/content/abstract/43/1/175 ], Edward J.
Calabrese - edwardcschoolph.umass.edu, Linda A. Baldwin -
lbaldwinschoolph.umass.edu, Annu. Rev. Pharmacol. Toxicol. 2003. 43:175-197.

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