Antidepressants Need New Nerve Cells To Be Effective, Researchers Find, ScienceDaily Bookmark and Share

Excerpts: Researchers at UT Southwestern Medical Center have discovered in mice that the brain must create new nerve cells for either exercise or antidepressants to reduce depression-like behavior. In addition, the researchers found that antidepressants and exercise use the same biochemical pathway to exert their effects. These results might help explain some unknown mechanisms of antidepressants (...). In animals, it was already known that long-term treatment with antidepressants causes new nerve cells to be generated in a part of the brain called the dentate gyrus. Exercise, which can also relieve the symptoms of depression, stimulates the generation of new nerve cells in the same area. (...)